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Article

Human β-Defensin 2 Mutations Are Associated With Asthma and Atopy in Children and Its Application Prevents Atopic Asthma in a Mouse Model.

Frontiers in immunology - 1 Jan 2021

Borchers Natascha S, Santos-Valente Elisangela, Toncheva Antoaneta A, Wehkamp Jan, Franke Andre, Gaertner Vincent D, Nordkild Peter, Genuneit Jon, Jensen Benjamin A H, Kabesch Michael

Abstract excerpt

Asthma and allergies are complex, chronic inflammatory diseases in which genetic and environmental factors are crucial. Protection against asthma and allergy development in the context of farming environment is established by early animal contact, unpasteurized milk consumption and gut microbiota maturation. The human β-defensin 2 (hBD-2) is a host defense peptide present almost exclusively in epithelial tissues,...

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Identifiers

PMID: 33717182
DOI: 10.3389/fimmu.2021.636061
PMCID: PMC7946850

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