Article
TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples.
American journal of respiratory and critical care medicine - 15 Sept 2004
Lazarus Ross, Raby Benjamin A, Lange Christoph, Silverman Edwin K, Kwiatkowski David J, Vercelli Donata, Klimecki Walt J, Martinez Fernando D, Weiss Scott T
Abstract excerpt
TOLL-like receptor 10 (TLR10) is the most recently identified human homolog of the Drosophila TOLL protein. In humans, the TOLL-like receptors recognize pathogen-associated molecular patterns (PAMPs) as part of innate immune host defenses. Localized to chromosome 4p14, the specific ligands and functions of TLR10 are currently unknown, although it is expressed in lung and in B-lymphocytes. TLR10 is a potential...
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