NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity.

doi:10.1016/j.jaci.2020.12.636

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Article

NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity.

The Journal of allergy and clinical immunology - 1 Jun 2021

Moecking Jonas, Laohamonthonkul Pawat, Chalker Katelyn, White Marquitta J, Harapas Cassandra R, Yu Chien-Hsiung, Davidson Sophia, Hrovat-Schaale Katja, Hu Donglei, Eng Celeste, Huntsman Scott, Calleja Dale J, Horvat Jay C, Hansbro Phil M, O'Donoghue Robert J J, Ting Jenny P, Burchard Esteban G, Geyer Matthias, Gerlic Motti, Masters Seth L

Abstract excerpt

BACKGROUND: NLRP1 is an innate immune sensor that can form cytoplasmic inflammasome complexes. Polymorphisms in NLRP1 are linked to asthma; however, there is currently no functional or mechanistic explanation for this. OBJECTIVE: We sought to clarify the role of NLRP1 in asthma pathogenesis. METHODS: Results from the GALA II cohort study were used to identify a link between NLRP1 and asthma in Mexican Americans....

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Identifiers

PMID: 33378691
DOI: 10.1016/j.jaci.2020.12.636
PMCID: PMC8168955

Genes

NLRP1
DPP9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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