Article
Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice.
Disease models & mechanisms - 7 Feb 2018
Rogala Allison R, Schoenborn Alexi A, Fee Brian E, Cantillana Viviana A, Joyce Maria J, Gharaibeh Raad Z, Roy Sayanty, Fodor Anthony A, Sartor R Balfour, Taylor Gregory A, Gulati Ajay S
Abstract excerpt
Crohn's disease (CD) represents a chronic inflammatory disorder of the intestinal tract. Several susceptibility genes have been linked to CD, though their precise role in the pathogenesis of this disorder remains unclear. Immunity-related GTPase M (IRGM) is an established risk allele in CD. We have shown previously that conventionally raised (CV) mice lacking the IRGM ortholog, Irgm1 exhibit abnormal Paneth cells...
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