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Article

The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche.

Nature communications - 28 Mar 2018

Sehgal Anuj, Donaldson David S, Pridans Clare, Sauter Kristin A, Hume David A, Mabbott Neil A

Abstract excerpt

Colony-stimulating factor 1 (CSF1) controls the growth and differentiation of macrophages.CSF1R signaling has been implicated in the maintenance of the intestinal stem cell niche and differentiation of Paneth cells, but evidence of expression of CSF1R within the crypt is equivocal. Here we show that CSF1R-dependent macrophages influence intestinal epithelial differentiation and homeostasis. In the intestinal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29593242
DOI: 10.1038/s41467-018-03638-6
PMCID: PMC5871851

Genes

CSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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