Article

Intraepithelial lymphocytes exhibit selective immunity to intestinal pathogens

2025-05-17

Abstract excerpt

Intraepithelial lymphocytes (IEL) are abundant, tissue-resident T cells critical for intestinal immune surveillance, yet their precise roles have remained elusive due to the lack of models enabling their selective genetic ablation. Here, we report the generation of Gzmb -Cre knock-in mice, that when crossed with inducible Diphtheria toxin receptor mice, allows targeted and inducible ablation of IELs without pertu...

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Literature Corpus work: 3a974a0d-d095-57ec-b79e-d513d984da2d
DOI: 10.1101/2025.05.14.654011

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