Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration.

Gut - 1 Dec 2014

Tschurtschenthaler Markus, Wang Jun, Fricke Cornelia, Fritz Teresa M J, Niederreiter Lukas, Adolph Timon E, Sarcevic Edina, Künzel Sven, Offner Felix A, Kalinke Ulrich, Baines John F, Tilg Herbert, Kaser Arthur

Abstract excerpt

OBJECTIVE: Intestinal epithelial cells (IECs) at the internal/external interface orchestrate the mucosal immune response. Paneth cells secrete antimicrobial peptides and inflammatory mediators, protect from pathogens and shape the commensal microbiota. Prompted by the genetic association of the locus harbouring the type I interferon (IFN) receptor (IFNAR1) with Crohn's disease, and a transcriptional signature for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimicrobial Cationic Peptides
Share to Colitis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dextran Sulfate

Share to Goblet Cells

Share to Immunity, Mucosal

Share to Microbiota

Share to Paneth Cells

Share to Receptor, Interferon alpha-beta

Source

Identifiers

PMID: 24555997
DOI: 10.1136/gutjnl-2013-305863

Genes

IFNAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration.PMID 24555997Read ↗

Type I interferon signaling promotes mucosal inflammation in murine models of colitisSemantic proximity Read ↗

A homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epitheliumSemantic proximity Read ↗

Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epitheliumSemantic proximity Read ↗

Plasmacytoid dendritic cells in the intestine preferentially produce interferon lambda at homeostasis contributing to tonic localized innate immune responsesSemantic proximity Read ↗

Inactivation of Interferon Regulatory Factor 1 Causes Susceptibility to Colitis-Associated Colorectal Cancer.Semantic proximity Read ↗

Inflammatory bowel disease pathobiology: the role of the interferon signatureSemantic proximity Read ↗

Elucidating early intestinal stem cell response to bacterial infectionSemantic proximity Read ↗

Analysis of intestinal epithelial cell responses to Cryptosporidium highlights the temporal effects of IFN-γ on parasite restrictionSemantic proximity Read ↗

TL1A overexpression in Crohn’s Disease and mice alters Paneth cells and microbiota promoting ileal inflammationSemantic proximity Read ↗

Innate immunity of the gut epithelium: Blowing in the WNT?Semantic proximity Read ↗

Paneth cells and innate mucosal immunitySemantic proximity Read ↗

Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.