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Article

Importance of phosphoinositide binding by human β-defensin 3 for Akt-dependent cytokine induction.

Immunology and cell biology - 1 Jan 2018

Phan Thanh Kha, Lay Fung T, Hulett Mark D

Abstract excerpt

Host defense peptides (HDPs) are well-characterized for their antimicrobial activities but also variously display potent immunomodulatory effects. Human β-defensin 3 (HBD-3) belongs to a well-known HDP family known as defensins and is able to induce leukocyte chemotactic recruitment, leukocyte activation/maturation, proinflammatory cytokine release, and co-stimulatory marker expression. HBD-3-stimulated cytokine...

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Source

Identifiers

PMID: 29359392
DOI: 10.1111/imcb.1017

Genes

HBD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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