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Article

Two modes of beta-receptor recognition are mediated by distinct epitopes on mouse and human interleukin-3.

The Journal of biological chemistry - 16 Jul 2010

Mirza Shamaruh, Chen Jinglong, Wen Bin, Ewens Cameron L, Dai Jin, Murphy James M, Young Ian G

Abstract excerpt

The cytokine interleukin-3 (IL-3) is a critical regulator of inflammation and immune responses in mammals. IL-3 exerts its effects on target cells via receptors comprising an IL-3-specific alpha-subunit and common beta-subunit (beta c; shared with IL-5 and granulocyte-macrophage colony-stimulating factor) or a beta-subunit that specifically binds IL-3 (beta(IL-3); present in mice but not humans). We recently...

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Identifiers

PMID: 20472554
DOI: 10.1074/jbc.M110.117465
PMCID: PMC2903361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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