Article
Molecular and functional analysis of human β-defensin 3 action at melanocortin receptors.
Chemistry & biology - 20 Jun 2013
Nix Matthew A, Kaelin Christopher B, Ta Tina, Weis Allison, Morton Gregory J, Barsh Gregory S, Millhauser Glenn L
Abstract excerpt
The β-defensins are a class of small, cationic proteins first recognized as antimicrobial components of the innate and adaptive immune system. More recently, one of the major β-defensins produced in skin, β-defensin 3, has been discovered to function as a melanocortin receptor ligand in vivo and in vitro, but its biophysical and pharmacological basis of action has been enigmatic. Here, we report functional and...
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