Article
IL-2 triggers specific signaling pathways in human NKT cells leading to the production of pro- and anti-inflammatory cytokines.
Journal of leukocyte biology - 1 Jul 2008
Bessoles Stéphanie, Fouret Frédéric, Dudal Sherri, Besra Gurdyal S, Sanchez Françoise, Lafont Virginie
Abstract excerpt
NKT cells belong to a conserved T lymphocyte subgroup that has been implicated in the regulation of various immune responses, including responses to viruses, bacteria, and parasites. They express a semi-invariant TCR that recognizes glycolipids presented by the nonpolymorphic MHC class I-like molecule CD1d, and upon activation, they produce various pro- and anti-inflammatory cytokines. Recent studies have shed...
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