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Article

Classical macrophage polarisation is limited by human β-defensin-3 via an autocrine IL-4 dependent process

2021-05-06

Abstract excerpt

Human β-defensin 3 (HBD3), is an anti-microbial host-defence peptide, that can rapidly enter macrophages to modulate TLR4 responses to lipopolysaccharide. However, the molecular mechanisms by which HBD3 exerts this anti-inflammatory influence remain unclear. Here, we show mice deleted for the orthologue of HBD3 have an increased acute lipopolysaccharide response in vivo . Furthermore, we found that HBD3 limited t...

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Identifiers and source

Literature Corpus work
462c677f-0e16-5bc2-8381-b4d960924af7
DOI
10.1101/2021.05.06.442606
Open publication

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Classical macrophage polarisation is limited by human β-defensin-3 via an autocrine IL-4 dependent processDOI 10.1101/2021.05.06.442606
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