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P <scp>hosphoinositide</scp> 3-K <scp>inase</scp> : Diverse Roles in Immune Cell Activation

19 Mar 2004

Abstract excerpt

Cells of the immune system carry out diverse functions that are controlled by surface receptors for antigen, costimulatory molecules, cytokines, chemokines, and other ligands. A shared feature of signal transduction downstream of most receptors on immune cells, as in nonhematopoietic cell types, is the activation of phosphoinositide 3-kinase (PI3K). The mechanism by which this common signaling event is elicited...

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PMID: 15032589
DOI: 10.1146/annurev.immunol.22.012703.104721

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