Article
Modulation of host defense peptide-mediated human mast cell activation by LPS.
Innate immunity - 1 Jan 2016
Gupta Kshitij, Subramanian Hariharan, Ali Hydar
Abstract excerpt
Human β-defensin3 (hBD3) and the cathelicidin LL-37 are host defense peptides (HDPs) that directly kill microbes and display immunomodulatory/wound-healing properties via the activation of chemokine, formylpeptide and epidermal growth factor receptors on leukocytes and epithelial cells. A C-terminal 14 amino acid hBD3 peptide with all Cys residues replaced with Ser (CHRG01) and an LL-37 peptide consisting of...
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