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Cutting Edge: Human β Defensin 3—A Novel Antagonist of the HIV-1 Coreceptor CXCR4

1 Jul 2006

Abstract excerpt

Previously, we showed that human epithelial cell-derived beta-defensins (hBD)-2 and -3 block HIV-1 replication via a direct interaction with virions and through modulation of the CXCR4 coreceptor on immunocompetent cells. In the present study, we show that hBD-3 promotes directly the internalization of CXCR4 yet does not induce calcium flux, ERK (ERK-1/2) phosphorylation, or chemotaxis. hBD-3 competes with...

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PMID: 16818731
DOI: 10.4049/jimmunol.177.2.782

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