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Article

p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons.

The EMBO journal - 15 Oct 1999

Goh K C, Haque S J, Williams B R

Abstract excerpt

Activation of cytosolic phospholipase A(2 )(cPLA(2)) is a prerequisite for the formation of the transcription factor complex interferon-stimulated gene factor 3 (ISGF3) in response to interferon-alpha (IFN-alpha). Here we show that p38 mitogen-activated protein kinase (MAPK), an activator of cPLA(2), is essential for both IFN-alpha and IFN-gamma signalling. SB203580, a specific inhibitor of p38, was found to...

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Source

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Identifiers

PMID: 10523304
DOI: 10.1093/emboj/18.20.5601
PMCID: PMC1171628

Genes

STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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