Article
Staphylococcal enterotoxin C2 mutant drives T lymphocyte activation through PI3K/mTOR and NF-ĸB signaling pathways.
Toxicology and applied pharmacology - 15 Oct 2017
Fu Xuanhe, Xu Mingkai, Yao Songyuan, Zhang Huiwen, Zhang Chenggang, Zhang Jinghai
Abstract excerpt
Staphylococcal enterotoxin C2 (SEC2), a superantigen, causes rapid clonal expansion of lymphocytes and secretion of T cell growth factors, leading to a severe inflammatory response within tissues. Although previous studies have shown that ST-4, a SEC2 mutant with enhanced recognition of Vβ regions of T-cell receptors (TCRVβ), can activate an increased number of T cells and produce more cytokines than SEC2....
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