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Article

The properties of human disease mutations at protein interfaces.

PLoS computational biology - 1 Feb 2022

Livesey Benjamin J, Marsh Joseph A

Abstract excerpt

The assembly of proteins into complexes and their interactions with other biomolecules are often vital for their biological function. While it is known that mutations at protein interfaces have a high potential to be damaging and cause human genetic disease, there has been relatively little consideration for how this varies between different types of interfaces. Here we investigate the properties of human...

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Identifiers

PMID: 35120134
DOI: 10.1371/journal.pcbi.1009858
PMCID: PMC8849535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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