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Article

Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2018

Starke Robert M, Thompson John W, Ali Muhammad S, Pascale Crissey L, Martinez Lege Alejandra, Ding Dale, Chalouhi Nohra, Hasan David M, Jabbour Pascal, Owens Gary K, Toborek Michal, Hare Joshua M, Dumont Aaron S

Abstract excerpt

OBJECTIVE: Cigarette smoke exposure (CSE) is a risk factor for cerebral aneurysm (CA) formation, but the molecular mechanisms are unclear. Although CSE is known to contribute to excess reactive oxygen species generation, the role of oxidative stress on vascular smooth muscle cell (VSMC) phenotypic modulation and pathogenesis of CAs is unknown. The goal of this study was to investigate whether CSE activates a NOX...

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Share to Cerebral Arteries
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29348119
DOI: 10.1161/ATVBAHA.117.310478
PMCID: PMC5823774

Genes

NOX1
KLF4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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