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Article

Wall shear stress promotes intimal hyperplasia through the paracrine H2O2-mediated NOX-AKT-SVV axis.

Life sciences - 15 Aug 2018

Zhang Haolong, Yang Zhipeng, Wang Jing, Wang Xuehu, Zhao Yu, Zhu Fangyu

Abstract excerpt

AIMS: Oscillatory wall shear stress (WSS)-linked oxidative stress promotes intimal hyperplasia (IH) development, but the underlying mechanisms are not completely understood. MATERIALS AND METHODS: We used an in vivo rabbit carotid arterial stenosis model representing different levels of WSS and found that WSS was increased at 1 month with 50% stenosis and was accompanied by VSMCs proliferation and interstitial...

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Source

Identifiers

PMID: 29847774
DOI: 10.1016/j.lfs.2018.05.045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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