Article
Nox2-derived superoxide contributes to cerebral vascular dysfunction in diet-induced obesity.
Stroke - 1 Nov 2013
Lynch Cynthia M, Kinzenbaw Dale A, Chen Xunxheng, Zhan Shanshan, Mezzetti Erin, Filosa Jessica, Ergul Adviye, Faulkner Jessica L, Faraci Frank M, Didion Sean P
Abstract excerpt
BACKGROUND AND PURPOSE: Obesity is an increasing epidemic worldwide; however, little is known about effects of obesity produced by high-fat diet (HFD) on the cerebral circulation. The purpose of this study was to examine the functional and temporal effects of a HFD on carotid and cerebral vascular function and to identify mechanisms that contribute to such functional alterations. METHODS: Responses of cerebral...
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