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Article

HMGB1 promotes intracranial aneurysm progression by regulating vascular smooth muscle cell phenotypic switching and ferroptosis.

Journal of molecular histology - 8 Jun 2026

Zhu Huaxin, Zeng Yanyang, Xiao Zhipeng, Tan Jiacong, Xin Wenqiang, Zheng Zhifan, Zhao Yeyu, Li Meihua

Abstract excerpt

Phenotypic switching in vascular smooth muscle cells (VSMCs) is key to the formation and progression of intracranial aneurysms (IAs). High-mobility group box 1 (HMGB1), a damage-associated molecule, significantly influences the progression of various diseases. Ferroptosis is an iron-dependent cell death process that is controlled by extensive membrane damage induced by lipid peroxidation. However, few studies...

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Share to Cell Proliferation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ferroptosis

Share to HMGB1 Protein

Share to Intracranial Aneurysm

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

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Source

Identifiers

PMID: 42257786
DOI: 10.1007/s10735-026-10844-w

Genes

HMGB1
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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