Article

Aging-Associated <i>Nox4</i> -Mediated Mitochondrial ROS and DNA Damage Promote Vascular Cell Reprogramming and Aortic Remodeling in Abdominal Aneurysms

2025-07-14

Abstract excerpt

<h4> Abstract </h4> <h4>Background</h4> Aging and male sex are major risk factors for abdominal aortic aneurysm (AAA), a disease characterized by vascular cell phenotypic switching and aortic wall remodeling. Mitochondrial oxidative stress (mtOS) has been implicated in these changes. We previously demonstrated that NOX4 expression and activity increase with age in cardiovascular cells, promoting mtOS and vascul...

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Literature Corpus work: 26e09d8d-510c-5c50-9989-42bf92168d4c
DOI: 10.1101/2025.07.09.664017

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