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Article

Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification.

Circulation research - 11 Sept 2020

Furmanik Malgorzata, Chatrou Martijn, van Gorp Rick, Akbulut Asim, Willems Brecht, Schmidt Harald, van Eys Guillaume, Bochaton-Piallat Marie-Luce, Proudfoot Diane, Biessen Erik, Hedin Ulf, Perisic Ljubica, Mees Barend, Shanahan Catherine, Reutelingsperger Chris, Schurgers Leon

Abstract excerpt

RATIONALE: Vascular calcification, the formation of calcium phosphate crystals in the vessel wall, is mediated by vascular smooth muscle cells (VSMCs). However, the underlying molecular mechanisms remain elusive, precluding mechanism-based therapies. OBJECTIVE: Phenotypic switching denotes a loss of contractile proteins and an increase in migration and proliferation, whereby VSMCs are termed synthetic. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32564697
DOI: 10.1161/CIRCRESAHA.119.316159

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