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Article

Cigarette smoke modulates vascular smooth muscle phenotype: implications for carotid and cerebrovascular disease.

PloS one - 1 Jan 2013

Starke Robert M, Ali Muhammad S, Jabbour Pascal M, Tjoumakaris Stavropoula I, Gonzalez Fernando, Hasan David M, Rosenwasser Robert H, Owens Gary K, Koch Walter J, Dumont Aaron S

Abstract excerpt

BACKGROUND: The role of smooth muscle cell (SMC) phenotypic modulation in the cerebral circulation and pathogenesis of stroke has not been determined. Cigarette smoke is a major risk factor for atherosclerosis, but potential mechanisms are unclear, and its role in SMC phenotypic modulation has not been established. METHODS AND RESULTS: In cultured cerebral vascular SMCs, exposure to cigarette smoke extract (CSE)...

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Identifiers

PMID: 23967268
DOI: 10.1371/journal.pone.0071954
PMCID: PMC3743809

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KLF4
TNF

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