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Article

Inhibition of reactive oxygen species generation attenuates TLR4-mediated proinflammatory and proliferative phenotype of vascular smooth muscle cells.

Laboratory investigation; a journal of technical methods and pathology - 1 Aug 2013

Pi Yan, Zhang Li-Li, Li Bing-Hu, Guo Lu, Cao Xiao-Jie, Gao Chang-Yue, Li Jing-Cheng

Abstract excerpt

Reactive oxygen species (ROS) are associated with inflammation and vasculature dysfunction. This study aimed to investigate the potential role of the ROS on vascular Toll-like receptor 4 (TLR4)-mediated proinflammatory and proliferative phenotype of vascular smooth muscle cells (VSMCs). A wire-induced carotid injury model was used in male TLR4-deficient (TLR4(-/-)) and wild-type C57BL/6J mice to induce neointima...

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Source

Identifiers

PMID: 23774581
DOI: 10.1038/labinvest.2013.79

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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