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Article

Functional characterization of 9 CYP2A13 allelic variants by assessment of nicotine C-oxidation and coumarin 7-hydroxylation.

Drug metabolism and pharmacokinetics - 1 Feb 2018

Kumondai Masaki, Hosono Hiroki, Maekawa Masamitsu, Yamaguchi Hiroaki, Mano Nariyasu, Oda Akifumi, Hirasawa Noriyasu, Hiratsuka Masahiro

Abstract excerpt

Cytochrome P450 2A13 (CYP2A13) is responsible for the metabolism of chemical compounds such as nicotine, coumarin, and tobacco-specific nitrosamine. Several of these compounds have been recognized as procarcinogens activated by CYP2A13. We recently showed that CYP2A13*2 contributes to inter-individual variations observed in bladder cancer susceptibility because CYP2A13*2 might cause a decrease in enzymatic...

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PMID: 29342418
DOI: 10.1016/j.dmpk.2017.11.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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