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Article

The effects of single nucleotide polymorphisms in CYP2A13 on metabolism of 5-methoxypsoralen.

Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2010

Goto Tatsushi, Moriuchi Hiroshi, Fu Xuejun, Ikegawa Tomoyo, Matsubara Toshiyuki, Chang Gang, Uno Tomohide, Morigaki Kenichi, Isshiki Kunio, Imaishi Hiromasa

Abstract excerpt

A number of studies have demonstrated that cytochrome P450 (P450) converts furanocoumarin derivatives into reactive molecules, which form covalent bonds to biomolecules. 5-Methoxypsoralen (5-MOP) is a natural furanocoumarin from apiaceous plants. In this study, we examined the effect on 5-MOP metabolism of single nucleotide polymorphisms (SNPs) in CYP2A13. We used Escherichia coli-generated recombinant enzymes of...

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Identifiers

PMID: 20798279
DOI: 10.1124/dmd.110.034553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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