Article
Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers.
Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2008
D'Agostino Jaime, Zhang Xiuling, Wu Hong, Ling Guoyu, Wang Suping, Zhang Qing-Yu, Liu Fucai, Ding Xinxin
Abstract excerpt
CYP2A13, a human cytochrome P450 enzyme expressed mainly in the respiratory tract, is believed to play an important role in the initiation of smoking-induced lung cancer. CYP2A13.1 has high efficiency in the metabolic activation of a major tobacco-specific carcinogenic nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). CYP2A13(*)2, a variant allele, was previously found to be associated with...
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