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An investigation of the catalytic activity of CYP2A13*4 with coumarin and polymorphisms of CYP2A13 in a Chinese Han population.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2012

Liu Ting, Hong Yanjun, Li Zhaohui, Hong Junyan, Zeng Su, Zheng Mingyue, Chen Shuqing

Abstract excerpt

CYP2A13 has been identified as an efficient catalyst for the metabolisms of coumarin, aflatoxin B(1) (AFB(1)), and several tobacco-specific carcinogens. The reported CYP2A13 polymorphisms with missense variations have been studied for their functional consequences, and CYP2A13*4 (R101Q) variant was found to be a null enzyme in metabolizing 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), AFB(1), and...

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Identifiers

PMID: 22315333
DOI: 10.1124/dmd.111.044016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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