Article
Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK.
Cancer research - 15 Nov 2003
Wang Haijian, Tan Wen, Hao Bingtao, Miao Xiaoping, Zhou Gangqiao, He Fuchu, Lin Dongxin
Abstract excerpt
Cytochrome P450 2A13 (CYP2A13), an enzyme expressed predominantly in the human respiratory tract, exhibits high efficiency in the metabolic activation of tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). A C-->T transition in the CYP2A13 gene causes Arg257Cys amino acid sub...
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