Article
Novel single nucleotide polymorphism of the CYP2A13 gene in Japanese individuals.
Drug metabolism and pharmacokinetics - 1 Jan 2011
Tamaki Yuichiro, Honda Masashi, Muroi Yuka, Arai Tomio, Sugimura Haruhiko, Matsubara Yoichi, Kanno Shuichi, Ishikawa Masaaki, Hirasawa Noriyasu, Hiratsuka Masahiro
Abstract excerpt
Cytochrome P450 2A13 (CYP2A13) is a human CYP enzyme that is selectively expressed in the respiratory tract. It plays an active role in the metabolic activation of a tobacco-specific procarcinogen. In this study, the entire coding sequence and the exon-intron junctions of the CYP2A13 gene obtained from 395 Japanese individuals were screened for genetic polymorphisms. Eight genetic polymorphisms were found, of...
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