Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The missense genetic polymorphisms of human CYP2A13: functional significance in carcinogen activation and identification of a null allelic variant.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Nov 2006

Wang Shou-Lin, He Xiao-Yang, Shen Jian, Wang Jia-Sheng, Hong Jun-Yan

Abstract excerpt

Cytochrome P450 2A13 (CYP2A13), an enzyme predominantly expressed in human respiratory tissues, is highly efficient for the metabolic activation of two suspected human lung carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and aflatoxin B1 (AFB1). Functional genetic polymorphisms of CYP2A13 may therefore be an important factor in human susceptibility to related lung cancers. Among the reported...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aflatoxin B1
Share to Aryl Hydrocarbon Hydroxylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinogens

Share to Cricetulus

Share to DNA Nucleotidyltransferases

Share to Microsomes

Share to Nitrosamines

Share to Spodoptera

Source

Identifiers

PMID: 16917071
DOI: 10.1093/toxsci/kfl081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The missense genetic polymorphisms of human CYP2A13: functional significance in carcinogen activation and identification of a null allelic variant.PMID 16917071Read ↗

Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant.Semantic proximity Read ↗

An investigation of the catalytic activity of CYP2A13*4 with coumarin and polymorphisms of CYP2A13 in a Chinese Han population.Semantic proximity Read ↗

Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility.Semantic proximity Read ↗

Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK.Semantic proximity Read ↗

Single nucleotide polymorphisms of the human cyp2a13 gene: evidence for a null allele.Semantic proximity Read ↗

Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers.Semantic proximity Read ↗

Arg257Cys polymorphism of CYP2A13 in a Chinese population.Semantic proximity Read ↗

Functional characterization of 9 CYP2A13 allelic variants by assessment of nicotine C-oxidation and coumarin 7-hydroxylation.Semantic proximity Read ↗

Novel single nucleotide polymorphism of the CYP2A13 gene in Japanese individuals.Semantic proximity Read ↗

CYP2A13 genetic polymorphism in French Caucasian, Gabonese and Tunisian populations.Semantic proximity Read ↗

Development of a real-time polymerase chain reaction-based method for the measurement of relative allelic expression and identification of CYP2A13 alleles with decreased expression in human lung.Semantic proximity Read ↗

Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone:<i>in vivo</i>studies using a CYP2A13-humanized mouse modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.