Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CYP2A13 Genetic Polymorphisms in Relation to the Risk of Bladder Cancer in Japanese Smokers.

Biological & pharmaceutical bulletin - 1 Jan 2016

Kumondai Masaki, Hosono Hiroki, Orikasa Kazuhiko, Arai Yoichi, Arai Tomio, Sugimura Haruhiko, Ozono Seiichiro, Sugiyama Takayuki, Takayama Tatsuya, Sasaki Takamitsu, Hirasawa Noriyasu, Hiratsuka Masahiro

Abstract excerpt

Tobacco-specific nitrosamines including 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N-nitrosonornicotine (NNN), which can be activated by the metabolic enzyme CYP2A13, are potent procarcinogens. Smoking plays a role in carcinogenesis in the human bladder, which expresses CYP2A13 at a relatively high level. Numerous genetic polymorphisms of CYP2A13 causing amino acid substitution might reduce CYP2A13...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Aryl Hydrocarbon Hydroxylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Asian People

Share to Case-Control Studies

Share to Odds Ratio

Share to Smoking

Share to Urinary Bladder Neoplasms

Source

Identifiers

PMID: 27725446
DOI: 10.1248/bpb.b16-00422

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CYP2A13 Genetic Polymorphisms in Relation to the Risk of Bladder Cancer in Japanese Smokers.PMID 27725446Read ↗

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism-related enzymes gene polymorphisms, NNK metabolites levels and urothelial carcinoma.Semantic proximity Read ↗

Novel single nucleotide polymorphism of the CYP2A13 gene in Japanese individuals.Semantic proximity Read ↗

Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer.Semantic proximity Read ↗

AKR1C2 genetic variants mediate tobacco carcinogens metabolism involving bladder cancer susceptibility.Semantic proximity Read ↗

CYP2E1 and NQO1 genotypes, smoking and bladder cancer.Semantic proximity Read ↗

Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK.Semantic proximity Read ↗

Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population.Semantic proximity Read ↗

Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China.Semantic proximity Read ↗

Association of genotypes of carcinogen-metabolizing enzymes and smoking status with bladder cancer in a Japanese population.Semantic proximity Read ↗

Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.Semantic proximity Read ↗

Arg257Cys polymorphism of CYP2A13 in a Chinese population.Semantic proximity Read ↗

An investigation of the catalytic activity of CYP2A13*4 with coumarin and polymorphisms of CYP2A13 in a Chinese Han population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.