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Article

Identification of 315 genes essential for early zebrafish development.

Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 2004

Amsterdam Adam, Nissen Robert M, Sun Zhaoxia, Swindell Eric C, Farrington Sarah, Hopkins Nancy

Abstract excerpt

We completed a large insertional mutagenesis screen in zebrafish to identify genes essential for embryonic and early larval development. We isolated 525 mutants, representing lesions in approximately 390 different genes, and we cloned the majority of these. Here we describe 315 mutants and the corresponding genes. Our data suggest that there are roughly 1,400 embryonic-essential genes in the fish. Thus, we have...

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Identifiers

PMID: 15256591
DOI: 10.1073/pnas.0403929101
PMCID: PMC516474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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