Article
Highly pathogenic adapted HIV-1 strains limit host immunity and dictate rapid disease progression.
AIDS (London, England) - 1 Jun 2014
Dalmau Judith, Rotger Margalida, Erkizia Itziar, Rauch Andri, Reche Pedro, Pino Maria, Esteve Anna, Palou Eduard, Brander Christian, Paredes Roger, Phung Pham, Clotet Bonaventura, Telenti Amalio, Martinez-Picado Javier, Prado Julia G
Abstract excerpt
OBJECTIVE: The study of HIV-1 rapid progressors has been limited to specific case reports. Nevertheless, identification and characterization of the viral and host factors involved in rapid progression are crucial when attempting to uncover the correlates of rapid disease outcome. DESIGN: We carried out comparative functional analyses in rapid progressors (n = 46) and standard progressors (n = 46) early after...
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