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Article

OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity.

The Journal of clinical investigation - 1 Feb 2018

Leblanc Alix F, Sprowl Jason A, Alberti Paola, Chiorazzi Alessia, Arnold W David, Gibson Alice A, Hong Kristen W, Pioso Marissa S, Chen Mingqing, Huang Kevin M, Chodisetty Vamsi, Costa Olivia, Florea Tatiana, de Bruijn Peter, Mathijssen Ron H, Reinbolt Raquel E, Lustberg Maryam B, Sucheston-Campbell Lara E, Cavaletti Guido, Sparreboom Alex, Hu Shuiying

Abstract excerpt

Paclitaxel is among the most widely used anticancer drugs and is known to cause a dose-limiting peripheral neurotoxicity, the initiating mechanisms of which remain unknown. Here, we identified the murine solute carrier organic anion-transporting polypeptide B2 (OATP1B2) as a mediator of paclitaxel-induced neurotoxicity. Additionally, using established tests to assess acute and chronic paclitaxel-induced...

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Identifiers

PMID: 29337310
DOI: 10.1172/JCI96160
PMCID: PMC5785270

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