Article

Degraded myelin is associated with cold hypersensitivity in paclitaxel-induced peripheral neuropathy

2026-06-02

Abstract excerpt

Cold allodynia is a debilitating symptom of chemotherapy-induced peripheral neuropathy (CIPN), a side effect of many chemotherapeutics, including paclitaxel (PTX). CIPN is highly prevalent and can lead to cessation of chemotherapy, threatening cancer patient survival. PTX induces cold-evoked pain in 60% of CIPN patients and this pain is a predictor for more severe neuropathy. Cold is transduced by primary sensory...

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Literature Corpus work: 67e4bfaa-e7bc-5e05-954a-301107e581e3
DOI: 10.64898/2026.05.29.728780

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