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Article

Circadian regulation of chemotherapy-induced peripheral neuropathic pain and the underlying transcriptomic landscape

14 Aug 2020

Abstract excerpt

Growing evidence demonstrates circadian rhythms of pain hypersensitivity in various chronic disorders. In chemotherapy-induced peripheral neuropathy (CIPN), agents such as paclitaxel are known to elicit chronic neuropathic pain in cancer patients and seriously compromise their quality of life. Here, we report that the mechanical threshold for allodynia in paclitaxel-treated rats exhibited a robust circadian...

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PMID: 32796949
DOI: 10.1038/s41598-020-70757-w

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