Article

Na <sub>v</sub> 1.5 expressed in TrkB <sup>+</sup> sensory neurons mediates paclitaxel-induced mechanical pain hypersensitivity

2026-03-23

Abstract excerpt

Chemotherapy-induced neuropathic pain (CINP) is a frequent and debilitating adverse effect of anti-tumor therapies, for which current treatments are largely non-specific and offer limited efficacy. Identifying molecular mechanisms that drive CINP may enable the development of targeted therapeutic strategies. Here, we demonstrate that paclitaxel-induced mechanical pain hypersensitivity in mice occurs independently...

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Identifiers and source

Literature Corpus work: 714921f9-5f36-5363-aa6b-6adafce64a70
DOI: 10.64898/2026.03.19.713015

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