Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Macrophage Toll-like Receptor 9 Contributes to Chemotherapy-Induced Neuropathic Pain in Male Mice

3 Jul 2019

Abstract excerpt

Chemotherapy-induced peripheral neuropathy (CIPN) remains a pressing clinical problem; however, our understanding of sexual dimorphism in CIPN remains unclear. Emerging studies indicate a sex-dimorphic role of Toll-like receptor 4 (TLR4) in driving neuropathic pain. In this study, we examined the role of TLR9 in CIPN induced by paclitaxel in WT and Tlr9 mutant mice of both sexes. Baseline pain sensitivity was not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Stress, Anesthesia, and Immune Response
Share to Cancer Treatment and Pharmacology
Share to Pain Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31270160
DOI: 10.1523/jneurosci.3257-18.2019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Macrophage Toll-like Receptor 9 Contributes to Chemotherapy-Induced Neuropathic Pain in Male MicePMID 31270160Read ↗

A novel model of paclitaxel-induced peripheral neuropathy produces a clinically relevant phenotype in miceSemantic proximity Read ↗

Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice.Semantic proximity Read ↗

Transcriptome profiling of long noncoding RNAs and mRNAs in spinal cord of a rat model of paclitaxel-induced peripheral neuropathy identifies potential mechanisms mediating neuroinflammation and painSemantic proximity Read ↗

RNA Profiling of Neuropathic Pain-Associated Human DRGs Reveal Sex-differences in Neuro-immune Interactions Promoting PainSemantic proximity Read ↗

Proteomic Analysis of Dorsal Root Ganglia in a Mouse Model of Paclitaxel-Induced Neuropathic PainSemantic proximity Read ↗

Probing the peripheral immune response in mouse models of oxaliplatin-induced peripheral neuropathy highlights their limited translatabilitySemantic proximity Read ↗

Temporal Contribution of Myeloid-Lineage TLR4 to the Transition to Chronic Pain: A Focus on Sex DifferencesSemantic proximity Read ↗

Degraded myelin is associated with cold hypersensitivity in paclitaxel-induced peripheral neuropathySemantic proximity Read ↗

Na <sub>v</sub> 1.5 expressed in TrkB <sup>+</sup> sensory neurons mediates paclitaxel-induced mechanical pain hypersensitivitySemantic proximity Read ↗

Longitudinal RNA sequencing of skin and DRG neurons in mice with paclitaxel-induced peripheral neuropathySemantic proximity Read ↗

Neurobiology of Cancer Pain: A Narrative ReviewSemantic proximity Read ↗

Inducible co-stimulatory molecule (ICOS) alleviates Paclitaxel induced peripheral neuropathy via an IL-10-mediated mechanism in female miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.