Article

Single-Nuclei RNA Sequencing Identifies Type C Low-Threshold Mechanoreceptors as Key Players in Paclitaxel-Induced Peripheral Neuropathy

2024-01-01

Abstract excerpt

Neuropathic pain triggered by chemotherapy poses a significant clinical challenge. Investigating cell type-specific alterations through single-cell transcriptome analysis holds promise in understanding symptom development and pathogenesis. In this study, we performed single nuclei RNA (snRNA) sequencing of dorsal root ganglions (DRG) to explore the molecular mechanism underlying paclitaxel-induced neuropathic pain...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2f9038cd-c48e-579c-bd59-22f2325f4c5c
DOI: 10.1101/2023.12.31.573703

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-Nuclei RNA Sequencing Identifies Type C Low-Threshold Mechanoreceptors as Key Players in Paclitaxel-Induced Peripheral NeuropathyDOI 10.1101/2023.12.31.573703Read

Single-nucleus rna sequencing identifies universal camk1d upregulation and dysregulated c-ltmr subtypes as key drivers of paclitaxel-induced neuropathySemantic proximity Read

Na <sub>v</sub> 1.5 expressed in TrkB <sup>+</sup> sensory neurons mediates paclitaxel-induced mechanical pain hypersensitivitySemantic proximity Read

Transcriptome profiling of long noncoding RNAs and mRNAs in spinal cord of a rat model of paclitaxel-induced peripheral neuropathy identifies potential mechanisms mediating neuroinflammation and painSemantic proximity Read

Single-nucleus transcriptomic analysis of human dorsal root ganglion neuronsSemantic proximity Read

Single-cell transcriptomic profiling of dorsal root ganglion: an overviewSemantic proximity Read

Single nucleus transcriptomic analysis of human dorsal root ganglion neuronsSemantic proximity Read

Longitudinal RNA sequencing of skin and DRG neurons in mice with paclitaxel-induced peripheral neuropathySemantic proximity Read

Proteomic Analysis of Dorsal Root Ganglia in a Mouse Model of Paclitaxel-Induced Neuropathic PainSemantic proximity Read

Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of PaclitaxelSemantic proximity Read

Paclitaxel- and vincristine-induced neurotoxicity and drug transport in sensory neuronsSemantic proximity Read

Circadian regulation of chemotherapy-induced peripheral neuropathic pain and the underlying transcriptomic landscapeSemantic proximity Read

Single nucleus multiomic atlas of human dorsal root ganglia reveals the contribution of non-neuronal cell types to painSemantic proximity Read