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Article

Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development.

Journal of experimental & clinical cancer research : CR - 22 Oct 2021

Yang Yang, Zhao Bing, Gao Xuejiao, Sun Jinbing, Ye Juan, Li Jun, Cao Peng

Abstract excerpt

Oxaliplatin (OHP)-induced peripheral neurotoxicity (OIPN) is a severe clinical problem and potentially permanent side effect of cancer treatment. For the management of OIPN, accurate diagnosis and understanding of significant risk factors including genetic vulnerability are essential to improve knowledge regarding the prevalence and incidence of OIPN as well as enhance strategies for the prevention and treatment...

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Identifiers

PMID: 34686205
DOI: 10.1186/s13046-021-02141-z
PMCID: PMC8532307

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