Article

A novel model of paclitaxel-induced peripheral neuropathy produces a clinically relevant phenotype in mice

2025-02-11

Abstract excerpt

One of the most common adverse side effects of chemotherapeutics is chemotherapy-induced peripheral neuropathy (CIPN). Paclitaxel, a highly effective chemotherapeutic, is associated with a high incidence of paclitaxel-induced peripheral neuropathy (PIPN) that persists for over a year in 64% of patients and worsens with cumulative PTX dose. Patients experiencing PIPN may reduce the dosage of chemotherapy or halt tr...

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Literature Corpus work: b21ca665-1ffe-565d-b568-49d132bccd32
DOI: 10.1101/2025.02.10.637458

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