Article
The impact of SBF2 on taxane-induced peripheral neuropathy.
PLoS genetics - 1 Jan 2022
Cunningham Geneva M, Shen Fei, Wu Xi, Cantor Erica L, Gardner Laura, Philips Santosh, Jiang Guanglong, Bales Casey L, Tan Zhiyong, Liu Yunlong, Wan Jun, Fehrenbacher Jill C, Schneider Bryan P
Abstract excerpt
Taxane-induced peripheral neuropathy (TIPN) is a devastating survivorship issue for many cancer patients. In addition to its impact on quality of life, this toxicity may lead to dose reductions or treatment discontinuation, adversely impacting survival outcomes and leading to health disparities in African Americans (AA). Our lab has previously identified deleterious mutations in SET-Binding Factor 2 (SBF2) that...
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