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Article

Role of Infiltrating Monocytes in the Development of Radiation-Induced Pulmonary Fibrosis.

Radiation research - 1 Mar 2018

Groves Angela M, Johnston Carl J, Williams Jacqueline P, Finkelstein Jacob N

Abstract excerpt

Lung exposure to radiation induces an injury response that includes the release of cytokines and chemotactic mediators; these signals recruit immune cells to execute inflammatory and wound-healing processes. However, radiation alters the pulmonary microenvironment, dysregulating the immune responses and preventing a return to homeostasis. Importantly, dysregulation is observed as a chronic inflammation, which can...

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Share to Dose-Response Relationship, Radiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29332538
DOI: 10.1667/RR14874.1
PMCID: PMC5862390

Genes

CCR2
CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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