Article
Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities.
Scientific reports - 6 Jan 2016
Teresa Pinto Ana, Laranjeiro Pinto Marta, Patrícia Cardoso Ana, Monteiro Cátia, Teixeira Pinto Marta, Filipe Maia André, Castro Patrícia, Figueira Rita, Monteiro Armanda, Marques Margarida, Mareel Marc, Dos Santos Susana Gomes, Seruca Raquel, Adolfo Barbosa Mário, Rocha Sónia, José Oliveira Maria
Abstract excerpt
In order to improve the efficacy of conventional radiotherapy, attention has been paid to immune cells, which not only modulate cancer cell response to therapy but are also highly recruited to tumours after irradiation. Particularly, the effect of ionizing radiation on macrophages, using therapeutically relevant doses, is not well understood. To evaluate how radiotherapy affects macrophage behaviour and...
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