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Article

Implicating exudate macrophages and Ly-6C(high) monocytes in CCR2-dependent lung fibrosis following gene-targeted alveolar injury.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2013

Osterholzer John J, Olszewski Michal A, Murdock Benjamin J, Chen Gwo-Hsiao, Erb-Downward John R, Subbotina Natalya, Browning Keely, Lin Yujing, Morey Roger E, Dayrit Jeremy K, Horowitz Jeffrey C, Simon Richard H, Sisson Thomas H

Abstract excerpt

The alveolar epithelium is characteristically abnormal in fibrotic lung disease, and we recently established a direct link between injury to the type II alveolar epithelial cell (AEC) and the accumulation of interstitial collagen. The mechanisms by which damage to the epithelium induces lung scar...

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Share to Alveolar Epithelial Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exudates and Transudates

Share to Pneumonia

Share to Pulmonary Alveoli

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Share to Receptors, CCR2

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Source

Open in PubMed Open full text

Identifiers

PMID: 23467934
DOI: 10.4049/jimmunol.1200604
PMCID: PMC3608799

Genes

CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23467934-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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