Article
Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct.
The Journal of biological chemistry - 23 Feb 2018
Yoon Jung-Hoon, Hodge Richard P, Hackfeld Linda C, Park Jeseong, Roy Choudhury Jayati, Prakash Satya, Prakash Louise
Abstract excerpt
Acrolein, an α,β-unsaturated aldehyde, is generated in vivo as the end product of lipid peroxidation and from metabolic oxidation of polyamines, and it is a ubiquitous environmental pollutant. The reaction of acrolein with the N2 of guanine in DNA leads to the formation of γ-hydroxy-1-N2-propano-2' deoxyguanosine (γ-HOPdG), which can exist in DNA in a ring-closed or a ring-opened form. Here, we identified the...
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