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Article

DNA polymerase λ promotes error-free replication through Watson-Crick impairing N1-methyl-deoxyadenosine adduct in conjunction with DNA polymerase ζ.

The Journal of biological chemistry - 1 Jul 2021

Yoon Jung-Hoon, Basu Debashree, Choudhury Jayati Roy, Prakash Satya, Prakash Louise

Abstract excerpt

In a previous study, we showed that replication through the N1-methyl-deoxyadenosine (1-MeA) adduct in human cells is mediated via three different Polι/Polθ, Polη, and Polζ-dependent pathways. Based on biochemical studies with these Pols, in the Polι/Polθ pathway, we inferred a role for Polι in the insertion of a nucleotide (nt) opposite 1-MeA and of Polθ in extension of synthesis from the inserted nt; in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34119520
DOI: 10.1016/j.jbc.2021.100868
PMCID: PMC8260881

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